Identification of a common variant with potential pleiotropic effect on risk of inflammatory bowel disease and colorectal cancer
Identifieur interne : 002C74 ( Main/Exploration ); précédent : 002C73; suivant : 002C75Identification of a common variant with potential pleiotropic effect on risk of inflammatory bowel disease and colorectal cancer
Auteurs : Hamed Khalili [États-Unis] ; Jian Gong [États-Unis] ; Hermann Brenner [Allemagne] ; Thomas R. Austin [États-Unis] ; Carolyn M. Hutter [États-Unis] ; Yoshifumi Baba [Japon] ; John A. Baron [États-Unis] ; Sonja I. Berndt [États-Unis] ; Stéphane Bézieau [France] ; Bette Caan [Canada] ; Peter T. Campbell [États-Unis] ; Jenny Chang-Claude [Allemagne] ; Stephen J. Chanock [États-Unis] ; Constance Chen [États-Unis] ; Li Hsu [États-Unis] ; Shuo Jiao [États-Unis] ; David V. Conti [États-Unis] ; David Duggan [États-Unis] ; Charles S. Fuchs [États-Unis] ; Manish Gala [États-Unis] ; Steven Gallinger [Canada] ; Robert W. Haile [États-Unis] ; Tabitha A. Harrison [États-Unis] ; Richard Hayes [États-Unis] ; Aditi Hazra [États-Unis] ; Brian Henderson [États-Unis] ; Chris Haiman [États-Unis] ; Michael Hoffmeister [Allemagne] ; John L. Hopper [Australie] ; Mark A. Jenkins [États-Unis] ; Laurence N. Kolonel [États-Unis] ; Sébastien Küry [France] ; Andrea Lacroix [États-Unis] ; Loic Le Marchand [États-Unis] ; Mathieu Lemire [Canada] ; Noralane M. Lindor [États-Unis] ; Jing Ma [États-Unis] ; Joann E. Manson [États-Unis] ; Teppei Morikawa [Japon] ; Hongmei Nan [États-Unis] ; Kimmie Ng [États-Unis] ; Polly A. Newcomb [États-Unis] ; Reiko Nishihara [États-Unis] ; John D. Potter [États-Unis, Nouvelle-Zélande] ; Conghui Qu [États-Unis] ; Robert E. Schoen [États-Unis] ; Fredrick R. Schumacher [États-Unis] ; Daniela Seminara [États-Unis] ; Darin Taverna [États-Unis] ; Stephen Thibodeau [États-Unis] ; Jean Wactawski-Wende [États-Unis] ; Emily White [États-Unis] ; Kana Wu [États-Unis] ; Brent W. Zanke [États-Unis] ; Graham Casey [États-Unis] ; Thomas J. Hudson [Canada, États-Unis] ; Peter Kraft [États-Unis] ; Ulrike Peters [États-Unis] ; Martha L. Slattery [États-Unis] ; Shuji Ogino [États-Unis] ; Andrew T. Chan [États-Unis]Source :
- Carcinogenesis [ 0143-3334 ] ; 2015.
Descripteurs français
- KwdFr :
- Fréquence d'allèle, Humains, Instabilité des microsatellites, Maladie de Crohn (), Maladie de Crohn (génétique), Maladie de Crohn (épidémiologie), Polymorphisme de nucléotide simple, Population d'origine européenne, Prédisposition génétique à une maladie, Rectocolite hémorragique (), Rectocolite hémorragique (génétique), Rectocolite hémorragique (épidémiologie), Risque, Répétitions microsatellites (génétique), Tumeurs colorectales (génétique), Tumeurs colorectales (épidémiologie), Tumeurs colorectales (étiologie), Étude d'association pangénomique.
- MESH :
- génétique : Maladie de Crohn, Rectocolite hémorragique, Répétitions microsatellites, Tumeurs colorectales.
- épidémiologie : Maladie de Crohn, Rectocolite hémorragique, Tumeurs colorectales.
- étiologie : Tumeurs colorectales.
- Fréquence d'allèle, Humains, Instabilité des microsatellites, Maladie de Crohn, Polymorphisme de nucléotide simple, Population d'origine européenne, Prédisposition génétique à une maladie, Rectocolite hémorragique, Risque, Étude d'association pangénomique.
English descriptors
- KwdEn :
- Colitis, Ulcerative (complications), Colitis, Ulcerative (epidemiology), Colitis, Ulcerative (genetics), Colorectal Neoplasms (epidemiology), Colorectal Neoplasms (etiology), Colorectal Neoplasms (genetics), Crohn Disease (complications), Crohn Disease (epidemiology), Crohn Disease (genetics), European Continental Ancestry Group, Gene Frequency, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Microsatellite Instability, Microsatellite Repeats (genetics), Polymorphism, Single Nucleotide, Risk.
- MESH :
- complications : Colitis, Ulcerative, Crohn Disease.
- epidemiology : Colitis, Ulcerative, Colorectal Neoplasms, Crohn Disease.
- etiology : Colorectal Neoplasms.
- genetics : Colitis, Ulcerative, Colorectal Neoplasms, Crohn Disease, Microsatellite Repeats.
- European Continental Ancestry Group, Gene Frequency, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Microsatellite Instability, Polymorphism, Single Nucleotide, Risk.
Abstract
We identified the minor allele (T) in SNP rs11676348 to have pleiotropic effect on risk of UC and CRC, particularly in tumors with an inflammatory component. Our findings offer the promise of risk stratification of UC patients for developing CRC.
Url:
DOI: 10.1093/carcin/bgv086
PubMed: 26071399
PubMed Central: 4573660
Affiliations:
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Chan School of Public Health</institution>,<addr-line>Boston</addr-line>,<addr-line>MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hsu, Li" sort="Hsu, Li" uniqKey="Hsu L" first="Li" last="Hsu">Li Hsu</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jiao, Shuo" sort="Jiao, Shuo" uniqKey="Jiao S" first="Shuo" last="Jiao">Shuo Jiao</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Conti, David V" sort="Conti, David V" uniqKey="Conti D" first="David V." last="Conti">David V. 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Fuchs</name><affiliation wicri:level="1"><nlm:aff id="AF0017"><institution>Department of Medical Oncology</institution>,<institution>Dana-Farber Cancer Institute</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0018"><institution>Department of Epidemiology</institution>,<institution>Indiana University School of Public Health</institution>,<addr-line>Indianapolis</addr-line>,<addr-line>IN</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gala, Manish" sort="Gala, Manish" uniqKey="Gala M" first="Manish" last="Gala">Manish Gala</name><affiliation wicri:level="1"><nlm:aff id="AF0001"><institution>Gastrointestinal Unit</institution>,<institution>Massachusetts General Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gallinger, Steven" sort="Gallinger, Steven" uniqKey="Gallinger S" first="Steven" last="Gallinger">Steven Gallinger</name><affiliation wicri:level="1"><nlm:aff id="AF0019"><institution>Department of Surgery, University Health Network Toronto General Hospital</institution>,<addr-line>Toronto</addr-line>,<addr-line>ON</addr-line>,<country>Canada</country>,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Haile, Robert W" sort="Haile, Robert W" uniqKey="Haile R" first="Robert W." last="Haile">Robert W. Haile</name><affiliation wicri:level="1"><nlm:aff id="AF0020"><institution>Stanford Cancer Institute</institution>,<addr-line>Palo Alto, CA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Harrison, Tabitha A" sort="Harrison, Tabitha A" uniqKey="Harrison T" first="Tabitha A." last="Harrison">Tabitha A. Harrison</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hayes, Richard" sort="Hayes, Richard" uniqKey="Hayes R" first="Richard" last="Hayes">Richard Hayes</name><affiliation wicri:level="1"><nlm:aff id="AF0021"><institution>Division of Epidemiology</institution>,<institution>New York University School of Medicine</institution>,<addr-line>New York, NY</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hazra, Aditi" sort="Hazra, Aditi" uniqKey="Hazra A" first="Aditi" last="Hazra">Aditi Hazra</name><affiliation wicri:level="1"><nlm:aff id="AF0018"><institution>Department of Epidemiology</institution>,<institution>Indiana University School of Public Health</institution>,<addr-line>Indianapolis</addr-line>,<addr-line>IN</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Henderson, Brian" sort="Henderson, Brian" uniqKey="Henderson B" first="Brian" last="Henderson">Brian Henderson</name><affiliation wicri:level="1"><nlm:aff id="AF0015"><institution>Keck School of Medicine</institution>,<institution>University of Southern California</institution>,<addr-line>Los Angles, CA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Haiman, Chris" sort="Haiman, Chris" uniqKey="Haiman C" first="Chris" last="Haiman">Chris Haiman</name><affiliation wicri:level="1"><nlm:aff id="AF0015"><institution>Keck School of Medicine</institution>,<institution>University of Southern California</institution>,<addr-line>Los Angles, CA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hoffmeister, Michael" sort="Hoffmeister, Michael" uniqKey="Hoffmeister M" first="Michael" last="Hoffmeister">Michael Hoffmeister</name><affiliation wicri:level="1"><nlm:aff id="AF0003"><institution>Division of Clinical Epidemiology and Aging Research</institution>,<institution>German Cancer Research Center</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation wicri:level="1"><nlm:aff id="AF0022"><institution>Melbourne School of Population Health</institution>,<institution>The University of Melbourne</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jenkins, Mark A" sort="Jenkins, Mark A" uniqKey="Jenkins M" first="Mark A." last="Jenkins">Mark A. Jenkins</name><affiliation wicri:level="1"><nlm:aff id="AF0021"><institution>Division of Epidemiology</institution>,<institution>New York University School of Medicine</institution>,<addr-line>New York, NY</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N." last="Kolonel">Laurence N. Kolonel</name><affiliation wicri:level="1"><nlm:aff id="AF0023"><institution>Epidemiology Program</institution>,<institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu, HI</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kury, Sebastien" sort="Kury, Sebastien" uniqKey="Kury S" first="Sébastien" last="Küry">Sébastien Küry</name><affiliation wicri:level="1"><nlm:aff id="AF0010"><institution>CHU Nantes, Service de Génétique Médicale</institution>,<addr-line>Nantes</addr-line>,<country>France</country>,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lacroix, Andrea" sort="Lacroix, Andrea" uniqKey="Lacroix A" first="Andrea" last="Lacroix">Andrea Lacroix</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Marchand, Loic Le" sort="Marchand, Loic Le" uniqKey="Marchand L" first="Loic Le" last="Marchand">Loic Le Marchand</name><affiliation wicri:level="1"><nlm:aff id="AF0023"><institution>Epidemiology Program</institution>,<institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu, HI</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lemire, Mathieu" sort="Lemire, Mathieu" uniqKey="Lemire M" first="Mathieu" last="Lemire">Mathieu Lemire</name><affiliation wicri:level="1"><nlm:aff id="AF0024"><institution>Ontario Institute for Cancer Research</institution>,<addr-line>Toronto, ON</addr-line>,<country>Canada</country>,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lindor, Noralane M" sort="Lindor, Noralane M" uniqKey="Lindor N" first="Noralane M." last="Lindor">Noralane M. Lindor</name><affiliation wicri:level="1"><nlm:aff id="AF0025"><institution>Department of Health Science Services, Mayo Clinic</institution>,<addr-line>Scottsdale</addr-line>,<addr-line>AZ</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name><affiliation wicri:level="1"><nlm:aff id="AF0018"><institution>Department of Epidemiology</institution>,<institution>Indiana University School of Public Health</institution>,<addr-line>Indianapolis</addr-line>,<addr-line>IN</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Manson, Joann E" sort="Manson, Joann E" uniqKey="Manson J" first="Joann E." last="Manson">Joann E. Manson</name><affiliation wicri:level="1"><nlm:aff id="AF0026"><institution>Department of Medicine</institution>,<institution>Brigham and Women’s Hospital</institution>,<addr-line>Boston</addr-line>,<addr-line>MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Morikawa, Teppei" sort="Morikawa, Teppei" uniqKey="Morikawa T" first="Teppei" last="Morikawa">Teppei Morikawa</name><affiliation wicri:level="1"><nlm:aff id="AF0027"><institution>Department of Pathology</institution>,<institution>The University of Tokyo Hospital</institution>,<addr-line>Tokyo</addr-line>,<country>Japan</country>,</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nan, Hongmei" sort="Nan, Hongmei" uniqKey="Nan H" first="Hongmei" last="Nan">Hongmei Nan</name><affiliation wicri:level="1"><nlm:aff id="AF0018"><institution>Department of Epidemiology</institution>,<institution>Indiana University School of Public Health</institution>,<addr-line>Indianapolis</addr-line>,<addr-line>IN</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ng, Kimmie" sort="Ng, Kimmie" uniqKey="Ng K" first="Kimmie" last="Ng">Kimmie Ng</name><affiliation wicri:level="1"><nlm:aff id="AF0017"><institution>Department of Medical Oncology</institution>,<institution>Dana-Farber Cancer Institute</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A." last="Newcomb">Polly A. Newcomb</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nishihara, Reiko" sort="Nishihara, Reiko" uniqKey="Nishihara R" first="Reiko" last="Nishihara">Reiko Nishihara</name><affiliation wicri:level="1"><nlm:aff id="AF0017"><institution>Department of Medical Oncology</institution>,<institution>Dana-Farber Cancer Institute</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0028"><institution>Department of Nutrition, Harvard School of Public Health</institution>,<addr-line>Boston</addr-line>,<addr-line>MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Potter, John D" sort="Potter, John D" uniqKey="Potter J" first="John D." last="Potter">John D. Potter</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0029"><institution>Department of Epidemiology</institution>,<institution>University of Washington</institution>,<addr-line>Seattle</addr-line>,<addr-line>WA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0030"><institution>Center for Public Health Research, Massey University</institution>,<addr-line>Wellington</addr-line>,<country>New Zealand</country>,</nlm:aff><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Qu, Conghui" sort="Qu, Conghui" uniqKey="Qu C" first="Conghui" last="Qu">Conghui Qu</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schoen, Robert E" sort="Schoen, Robert E" uniqKey="Schoen R" first="Robert E." last="Schoen">Robert E. Schoen</name><affiliation wicri:level="1"><nlm:aff id="AF0031"><institution>Department of Medicine and Epidemiology</institution>,<institution>University of Pittsburgh Medical Center</institution>,<addr-line>Pittsburgh</addr-line>,<addr-line>PA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R." last="Schumacher">Fredrick R. Schumacher</name><affiliation wicri:level="1"><nlm:aff id="AF0015"><institution>Keck School of Medicine</institution>,<institution>University of Southern California</institution>,<addr-line>Los Angles, CA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name><affiliation wicri:level="1"><nlm:aff id="AF0006"><institution>Division of Cancer Control and Population Sciences, National Cancer Institute</institution>,<addr-line>Bethesda</addr-line>,<addr-line>MD</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Taverna, Darin" sort="Taverna, Darin" uniqKey="Taverna D" first="Darin" last="Taverna">Darin Taverna</name><affiliation wicri:level="1"><nlm:aff id="AF0016"><institution>Systems Imagination, Computational Biology</institution>,<addr-line>Pheonix</addr-line>,<addr-line>AZ</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Thibodeau, Stephen" sort="Thibodeau, Stephen" uniqKey="Thibodeau S" first="Stephen" last="Thibodeau">Stephen Thibodeau</name><affiliation wicri:level="1"><nlm:aff id="AF0032"><institution>Department of Laboratory Medicine and Pathology, Mayo Clinic</institution>,<addr-line>Rochester</addr-line>,<addr-line>MN</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wactawski Wende, Jean" sort="Wactawski Wende, Jean" uniqKey="Wactawski Wende J" first="Jean" last="Wactawski-Wende">Jean Wactawski-Wende</name><affiliation wicri:level="1"><nlm:aff id="AF0033"><institution>Department of Social and Preventive Medicine</institution>,<institution>University of Buffalo</institution>,<addr-line>Buffalo</addr-line>,<addr-line>NY</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wu, Kana" sort="Wu, Kana" uniqKey="Wu K" first="Kana" last="Wu">Kana Wu</name><affiliation wicri:level="1"><nlm:aff id="AF0028"><institution>Department of Nutrition, Harvard School of Public Health</institution>,<addr-line>Boston</addr-line>,<addr-line>MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zanke, Brent W" sort="Zanke, Brent W" uniqKey="Zanke B" first="Brent W." last="Zanke">Brent W. Zanke</name><affiliation wicri:level="1"><nlm:aff id="AF0034"><institution>Clinical Epidemiology Program, Ottawa Hospital Research Institute</institution>,<addr-line>Ottawa</addr-line>,<addr-line>ON</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name><affiliation wicri:level="1"><nlm:aff id="AF0015"><institution>Keck School of Medicine</institution>,<institution>University of Southern California</institution>,<addr-line>Los Angles, CA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J." last="Hudson">Thomas J. Hudson</name><affiliation wicri:level="1"><nlm:aff id="AF0024"><institution>Ontario Institute for Cancer Research</institution>,<addr-line>Toronto, ON</addr-line>,<country>Canada</country>,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0035"><institution>Department of Medical Biophysics</institution>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<addr-line>ON</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation wicri:level="1"><nlm:aff id="AF0014"><institution>Program in Molecular and Genetic Epidemiology</institution>,<institution>Harvard T.H. Chan School of Public Health</institution>,<addr-line>Boston</addr-line>,<addr-line>MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0018"><institution>Department of Epidemiology</institution>,<institution>Indiana University School of Public Health</institution>,<addr-line>Indianapolis</addr-line>,<addr-line>IN</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Slattery, Martha L" sort="Slattery, Martha L" uniqKey="Slattery M" first="Martha L." last="Slattery">Martha L. Slattery</name><affiliation wicri:level="1"><nlm:aff id="AF0036"><institution>Department of Internal Medicine</institution>,<institution>University of Utah Health Sciences Center</institution>,<addr-line>Salt Lake City</addr-line>,<addr-line>UT</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ogino, Shuji" sort="Ogino, Shuji" uniqKey="Ogino S" first="Shuji" last="Ogino">Shuji Ogino</name><affiliation wicri:level="1"><nlm:aff id="AF0017"><institution>Department of Medical Oncology</institution>,<institution>Dana-Farber Cancer Institute</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0037"><institution>Department of Pathology</institution>,<institution>Brigham and Women’s Hospital</institution>,<addr-line>Boston</addr-line>,<addr-line>MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0038"><institution>Department of Epidemiology</institution>,<institution>Harvard T.H. Chan School of Public Health</institution>,<addr-line>Boston</addr-line>,<addr-line>MA</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T." last="Chan">Andrew T. Chan</name><affiliation wicri:level="1"><nlm:aff id="AF0001"><institution>Gastrointestinal Unit</institution>,<institution>Massachusetts General Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0018"><institution>Department of Epidemiology</institution>,<institution>Indiana University School of Public Health</institution>,<addr-line>Indianapolis</addr-line>,<addr-line>IN</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26071399</idno><idno type="pmc">4573660</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573660</idno><idno type="RBID">PMC:4573660</idno><idno type="doi">10.1093/carcin/bgv086</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000178</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000178</idno><idno type="wicri:Area/Pmc/Curation">000178</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000178</idno><idno type="wicri:Area/Pmc/Checkpoint">000F32</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000F32</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">002967</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002967</idno><idno type="wicri:Area/PubMed/Curation">002898</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002898</idno><idno type="wicri:Area/PubMed/Checkpoint">002898</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002898</idno><idno type="wicri:Area/Ncbi/Merge">002700</idno><idno type="wicri:Area/Ncbi/Curation">002700</idno><idno type="wicri:Area/Ncbi/Checkpoint">002700</idno><idno type="wicri:doubleKey">0143-3334:2015:Khalili H:identification:of:a</idno><idno type="wicri:Area/Main/Merge">002C74</idno><idno type="wicri:Area/Main/Curation">002C74</idno><idno type="wicri:Area/Main/Exploration">002C74</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Identification of a common variant with potential pleiotropic effect on risk of inflammatory bowel disease and colorectal cancer</title><author><name sortKey="Khalili, Hamed" sort="Khalili, Hamed" uniqKey="Khalili H" first="Hamed" last="Khalili">Hamed Khalili</name><affiliation wicri:level="1"><nlm:aff id="AF0001"><institution>Gastrointestinal Unit</institution>,<institution>Massachusetts General Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gong, Jian" sort="Gong, Jian" uniqKey="Gong J" first="Jian" last="Gong">Jian Gong</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="1"><nlm:aff id="AF0003"><institution>Division of Clinical Epidemiology and Aging Research</institution>,<institution>German Cancer Research Center</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0004"><institution>German Cancer Cosortium (DKTK)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Austin, Thomas R" sort="Austin, Thomas R" uniqKey="Austin T" first="Thomas R." last="Austin">Thomas R. Austin</name><affiliation wicri:level="1"><nlm:aff id="AF0005"><institution>Whitman College</institution>,<addr-line>Walla Walla, WA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hutter, Carolyn M" sort="Hutter, Carolyn M" uniqKey="Hutter C" first="Carolyn M." last="Hutter">Carolyn M. Hutter</name><affiliation wicri:level="1"><nlm:aff id="AF0006"><institution>Division of Cancer Control and Population Sciences, National Cancer Institute</institution>,<addr-line>Bethesda</addr-line>,<addr-line>MD</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Baba, Yoshifumi" sort="Baba, Yoshifumi" uniqKey="Baba Y" first="Yoshifumi" last="Baba">Yoshifumi Baba</name><affiliation wicri:level="1"><nlm:aff id="AF0007"><institution>Department of Gastroenterological Surgery</institution>,<institution>Kumamoto University</institution>,<addr-line>Kumamoto</addr-line>,<country>Japan</country>,</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Baron, John A" sort="Baron, John A" uniqKey="Baron J" first="John A." last="Baron">John A. Baron</name><affiliation wicri:level="1"><nlm:aff id="AF0008"><institution>Department of Medicine, School of Medicine</institution>,<institution>University of North Carolina</institution>,<addr-line>Chapel Hill</addr-line>,<addr-line>NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I." last="Berndt">Sonja I. Berndt</name><affiliation wicri:level="1"><nlm:aff id="AF0009"><institution>Division of Cancer Epidemiology and Genetics</institution>,<institution>National Cancer Institute</institution>,<addr-line>Bethesda</addr-line>,<addr-line>MD</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stéphane" last="Bézieau">Stéphane Bézieau</name><affiliation wicri:level="1"><nlm:aff id="AF0010"><institution>CHU Nantes, Service de Génétique Médicale</institution>,<addr-line>Nantes</addr-line>,<country>France</country>,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Caan, Bette" sort="Caan, Bette" uniqKey="Caan B" first="Bette" last="Caan">Bette Caan</name><affiliation wicri:level="1"><nlm:aff id="AF0011"><institution>Division of Hematology</institution>,<institution>Faculty of Medicine</institution>,<institution>The University of Ottawa</institution>,<addr-line>Ottawa</addr-line>,<addr-line>ON</addr-line>,<country>Canada</country>,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Campbell, Peter T" sort="Campbell, Peter T" uniqKey="Campbell P" first="Peter T." last="Campbell">Peter T. Campbell</name><affiliation wicri:level="1"><nlm:aff id="AF0012"><institution>Epidemiology Research Program, American Cancer Society</institution>,<addr-line>Atlanta</addr-line>,<addr-line>GA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation wicri:level="1"><nlm:aff id="AF0013"><institution>Division of Cancer Epidemiology</institution>,<institution>German Cancer Research Center</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation wicri:level="1"><nlm:aff id="AF0009"><institution>Division of Cancer Epidemiology and Genetics</institution>,<institution>National Cancer Institute</institution>,<addr-line>Bethesda</addr-line>,<addr-line>MD</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Constance" sort="Chen, Constance" uniqKey="Chen C" first="Constance" last="Chen">Constance Chen</name><affiliation wicri:level="1"><nlm:aff id="AF0014"><institution>Program in Molecular and Genetic Epidemiology</institution>,<institution>Harvard T.H. Chan School of Public Health</institution>,<addr-line>Boston</addr-line>,<addr-line>MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hsu, Li" sort="Hsu, Li" uniqKey="Hsu L" first="Li" last="Hsu">Li Hsu</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jiao, Shuo" sort="Jiao, Shuo" uniqKey="Jiao S" first="Shuo" last="Jiao">Shuo Jiao</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Conti, David V" sort="Conti, David V" uniqKey="Conti D" first="David V." last="Conti">David V. Conti</name><affiliation wicri:level="1"><nlm:aff id="AF0015"><institution>Keck School of Medicine</institution>,<institution>University of Southern California</institution>,<addr-line>Los Angles, CA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Duggan, David" sort="Duggan, David" uniqKey="Duggan D" first="David" last="Duggan">David Duggan</name><affiliation wicri:level="1"><nlm:aff id="AF0016"><institution>Systems Imagination, Computational Biology</institution>,<addr-line>Pheonix</addr-line>,<addr-line>AZ</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fuchs, Charles S" sort="Fuchs, Charles S" uniqKey="Fuchs C" first="Charles S." last="Fuchs">Charles S. Fuchs</name><affiliation wicri:level="1"><nlm:aff id="AF0017"><institution>Department of Medical Oncology</institution>,<institution>Dana-Farber Cancer Institute</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0018"><institution>Department of Epidemiology</institution>,<institution>Indiana University School of Public Health</institution>,<addr-line>Indianapolis</addr-line>,<addr-line>IN</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gala, Manish" sort="Gala, Manish" uniqKey="Gala M" first="Manish" last="Gala">Manish Gala</name><affiliation wicri:level="1"><nlm:aff id="AF0001"><institution>Gastrointestinal Unit</institution>,<institution>Massachusetts General Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gallinger, Steven" sort="Gallinger, Steven" uniqKey="Gallinger S" first="Steven" last="Gallinger">Steven Gallinger</name><affiliation wicri:level="1"><nlm:aff id="AF0019"><institution>Department of Surgery, University Health Network Toronto General Hospital</institution>,<addr-line>Toronto</addr-line>,<addr-line>ON</addr-line>,<country>Canada</country>,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Haile, Robert W" sort="Haile, Robert W" uniqKey="Haile R" first="Robert W." last="Haile">Robert W. Haile</name><affiliation wicri:level="1"><nlm:aff id="AF0020"><institution>Stanford Cancer Institute</institution>,<addr-line>Palo Alto, CA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Harrison, Tabitha A" sort="Harrison, Tabitha A" uniqKey="Harrison T" first="Tabitha A." last="Harrison">Tabitha A. Harrison</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hayes, Richard" sort="Hayes, Richard" uniqKey="Hayes R" first="Richard" last="Hayes">Richard Hayes</name><affiliation wicri:level="1"><nlm:aff id="AF0021"><institution>Division of Epidemiology</institution>,<institution>New York University School of Medicine</institution>,<addr-line>New York, NY</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hazra, Aditi" sort="Hazra, Aditi" uniqKey="Hazra A" first="Aditi" last="Hazra">Aditi Hazra</name><affiliation wicri:level="1"><nlm:aff id="AF0018"><institution>Department of Epidemiology</institution>,<institution>Indiana University School of Public Health</institution>,<addr-line>Indianapolis</addr-line>,<addr-line>IN</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Henderson, Brian" sort="Henderson, Brian" uniqKey="Henderson B" first="Brian" last="Henderson">Brian Henderson</name><affiliation wicri:level="1"><nlm:aff id="AF0015"><institution>Keck School of Medicine</institution>,<institution>University of Southern California</institution>,<addr-line>Los Angles, CA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Haiman, Chris" sort="Haiman, Chris" uniqKey="Haiman C" first="Chris" last="Haiman">Chris Haiman</name><affiliation wicri:level="1"><nlm:aff id="AF0015"><institution>Keck School of Medicine</institution>,<institution>University of Southern California</institution>,<addr-line>Los Angles, CA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hoffmeister, Michael" sort="Hoffmeister, Michael" uniqKey="Hoffmeister M" first="Michael" last="Hoffmeister">Michael Hoffmeister</name><affiliation wicri:level="1"><nlm:aff id="AF0003"><institution>Division of Clinical Epidemiology and Aging Research</institution>,<institution>German Cancer Research Center</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation wicri:level="1"><nlm:aff id="AF0022"><institution>Melbourne School of Population Health</institution>,<institution>The University of Melbourne</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jenkins, Mark A" sort="Jenkins, Mark A" uniqKey="Jenkins M" first="Mark A." last="Jenkins">Mark A. Jenkins</name><affiliation wicri:level="1"><nlm:aff id="AF0021"><institution>Division of Epidemiology</institution>,<institution>New York University School of Medicine</institution>,<addr-line>New York, NY</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N." last="Kolonel">Laurence N. Kolonel</name><affiliation wicri:level="1"><nlm:aff id="AF0023"><institution>Epidemiology Program</institution>,<institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu, HI</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kury, Sebastien" sort="Kury, Sebastien" uniqKey="Kury S" first="Sébastien" last="Küry">Sébastien Küry</name><affiliation wicri:level="1"><nlm:aff id="AF0010"><institution>CHU Nantes, Service de Génétique Médicale</institution>,<addr-line>Nantes</addr-line>,<country>France</country>,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lacroix, Andrea" sort="Lacroix, Andrea" uniqKey="Lacroix A" first="Andrea" last="Lacroix">Andrea Lacroix</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Marchand, Loic Le" sort="Marchand, Loic Le" uniqKey="Marchand L" first="Loic Le" last="Marchand">Loic Le Marchand</name><affiliation wicri:level="1"><nlm:aff id="AF0023"><institution>Epidemiology Program</institution>,<institution>University of Hawaii Cancer Center</institution>,<addr-line>Honolulu, HI</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lemire, Mathieu" sort="Lemire, Mathieu" uniqKey="Lemire M" first="Mathieu" last="Lemire">Mathieu Lemire</name><affiliation wicri:level="1"><nlm:aff id="AF0024"><institution>Ontario Institute for Cancer Research</institution>,<addr-line>Toronto, ON</addr-line>,<country>Canada</country>,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lindor, Noralane M" sort="Lindor, Noralane M" uniqKey="Lindor N" first="Noralane M." last="Lindor">Noralane M. Lindor</name><affiliation wicri:level="1"><nlm:aff id="AF0025"><institution>Department of Health Science Services, Mayo Clinic</institution>,<addr-line>Scottsdale</addr-line>,<addr-line>AZ</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name><affiliation wicri:level="1"><nlm:aff id="AF0018"><institution>Department of Epidemiology</institution>,<institution>Indiana University School of Public Health</institution>,<addr-line>Indianapolis</addr-line>,<addr-line>IN</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Manson, Joann E" sort="Manson, Joann E" uniqKey="Manson J" first="Joann E." last="Manson">Joann E. Manson</name><affiliation wicri:level="1"><nlm:aff id="AF0026"><institution>Department of Medicine</institution>,<institution>Brigham and Women’s Hospital</institution>,<addr-line>Boston</addr-line>,<addr-line>MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Morikawa, Teppei" sort="Morikawa, Teppei" uniqKey="Morikawa T" first="Teppei" last="Morikawa">Teppei Morikawa</name><affiliation wicri:level="1"><nlm:aff id="AF0027"><institution>Department of Pathology</institution>,<institution>The University of Tokyo Hospital</institution>,<addr-line>Tokyo</addr-line>,<country>Japan</country>,</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nan, Hongmei" sort="Nan, Hongmei" uniqKey="Nan H" first="Hongmei" last="Nan">Hongmei Nan</name><affiliation wicri:level="1"><nlm:aff id="AF0018"><institution>Department of Epidemiology</institution>,<institution>Indiana University School of Public Health</institution>,<addr-line>Indianapolis</addr-line>,<addr-line>IN</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ng, Kimmie" sort="Ng, Kimmie" uniqKey="Ng K" first="Kimmie" last="Ng">Kimmie Ng</name><affiliation wicri:level="1"><nlm:aff id="AF0017"><institution>Department of Medical Oncology</institution>,<institution>Dana-Farber Cancer Institute</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A." last="Newcomb">Polly A. Newcomb</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nishihara, Reiko" sort="Nishihara, Reiko" uniqKey="Nishihara R" first="Reiko" last="Nishihara">Reiko Nishihara</name><affiliation wicri:level="1"><nlm:aff id="AF0017"><institution>Department of Medical Oncology</institution>,<institution>Dana-Farber Cancer Institute</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0028"><institution>Department of Nutrition, Harvard School of Public Health</institution>,<addr-line>Boston</addr-line>,<addr-line>MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Potter, John D" sort="Potter, John D" uniqKey="Potter J" first="John D." last="Potter">John D. Potter</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0029"><institution>Department of Epidemiology</institution>,<institution>University of Washington</institution>,<addr-line>Seattle</addr-line>,<addr-line>WA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0030"><institution>Center for Public Health Research, Massey University</institution>,<addr-line>Wellington</addr-line>,<country>New Zealand</country>,</nlm:aff><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Qu, Conghui" sort="Qu, Conghui" uniqKey="Qu C" first="Conghui" last="Qu">Conghui Qu</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schoen, Robert E" sort="Schoen, Robert E" uniqKey="Schoen R" first="Robert E." last="Schoen">Robert E. Schoen</name><affiliation wicri:level="1"><nlm:aff id="AF0031"><institution>Department of Medicine and Epidemiology</institution>,<institution>University of Pittsburgh Medical Center</institution>,<addr-line>Pittsburgh</addr-line>,<addr-line>PA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R." last="Schumacher">Fredrick R. Schumacher</name><affiliation wicri:level="1"><nlm:aff id="AF0015"><institution>Keck School of Medicine</institution>,<institution>University of Southern California</institution>,<addr-line>Los Angles, CA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name><affiliation wicri:level="1"><nlm:aff id="AF0006"><institution>Division of Cancer Control and Population Sciences, National Cancer Institute</institution>,<addr-line>Bethesda</addr-line>,<addr-line>MD</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Taverna, Darin" sort="Taverna, Darin" uniqKey="Taverna D" first="Darin" last="Taverna">Darin Taverna</name><affiliation wicri:level="1"><nlm:aff id="AF0016"><institution>Systems Imagination, Computational Biology</institution>,<addr-line>Pheonix</addr-line>,<addr-line>AZ</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Thibodeau, Stephen" sort="Thibodeau, Stephen" uniqKey="Thibodeau S" first="Stephen" last="Thibodeau">Stephen Thibodeau</name><affiliation wicri:level="1"><nlm:aff id="AF0032"><institution>Department of Laboratory Medicine and Pathology, Mayo Clinic</institution>,<addr-line>Rochester</addr-line>,<addr-line>MN</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wactawski Wende, Jean" sort="Wactawski Wende, Jean" uniqKey="Wactawski Wende J" first="Jean" last="Wactawski-Wende">Jean Wactawski-Wende</name><affiliation wicri:level="1"><nlm:aff id="AF0033"><institution>Department of Social and Preventive Medicine</institution>,<institution>University of Buffalo</institution>,<addr-line>Buffalo</addr-line>,<addr-line>NY</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wu, Kana" sort="Wu, Kana" uniqKey="Wu K" first="Kana" last="Wu">Kana Wu</name><affiliation wicri:level="1"><nlm:aff id="AF0028"><institution>Department of Nutrition, Harvard School of Public Health</institution>,<addr-line>Boston</addr-line>,<addr-line>MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zanke, Brent W" sort="Zanke, Brent W" uniqKey="Zanke B" first="Brent W." last="Zanke">Brent W. Zanke</name><affiliation wicri:level="1"><nlm:aff id="AF0034"><institution>Clinical Epidemiology Program, Ottawa Hospital Research Institute</institution>,<addr-line>Ottawa</addr-line>,<addr-line>ON</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name><affiliation wicri:level="1"><nlm:aff id="AF0015"><institution>Keck School of Medicine</institution>,<institution>University of Southern California</institution>,<addr-line>Los Angles, CA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J." last="Hudson">Thomas J. Hudson</name><affiliation wicri:level="1"><nlm:aff id="AF0024"><institution>Ontario Institute for Cancer Research</institution>,<addr-line>Toronto, ON</addr-line>,<country>Canada</country>,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0035"><institution>Department of Medical Biophysics</institution>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<addr-line>ON</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation wicri:level="1"><nlm:aff id="AF0014"><institution>Program in Molecular and Genetic Epidemiology</institution>,<institution>Harvard T.H. Chan School of Public Health</institution>,<addr-line>Boston</addr-line>,<addr-line>MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0018"><institution>Department of Epidemiology</institution>,<institution>Indiana University School of Public Health</institution>,<addr-line>Indianapolis</addr-line>,<addr-line>IN</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Public Health Sciences Division</institution>,<institution>Fred Hutchinson Cancer Research Center</institution>,<addr-line>Seattle, WA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Slattery, Martha L" sort="Slattery, Martha L" uniqKey="Slattery M" first="Martha L." last="Slattery">Martha L. Slattery</name><affiliation wicri:level="1"><nlm:aff id="AF0036"><institution>Department of Internal Medicine</institution>,<institution>University of Utah Health Sciences Center</institution>,<addr-line>Salt Lake City</addr-line>,<addr-line>UT</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ogino, Shuji" sort="Ogino, Shuji" uniqKey="Ogino S" first="Shuji" last="Ogino">Shuji Ogino</name><affiliation wicri:level="1"><nlm:aff id="AF0017"><institution>Department of Medical Oncology</institution>,<institution>Dana-Farber Cancer Institute</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0037"><institution>Department of Pathology</institution>,<institution>Brigham and Women’s Hospital</institution>,<addr-line>Boston</addr-line>,<addr-line>MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0038"><institution>Department of Epidemiology</institution>,<institution>Harvard T.H. Chan School of Public Health</institution>,<addr-line>Boston</addr-line>,<addr-line>MA</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T." last="Chan">Andrew T. Chan</name><affiliation wicri:level="1"><nlm:aff id="AF0001"><institution>Gastrointestinal Unit</institution>,<institution>Massachusetts General Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0018"><institution>Department of Epidemiology</institution>,<institution>Indiana University School of Public Health</institution>,<addr-line>Indianapolis</addr-line>,<addr-line>IN</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Carcinogenesis</title><idno type="ISSN">0143-3334</idno><idno type="eISSN">1460-2180</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Colitis, Ulcerative (complications)</term><term>Colitis, Ulcerative (epidemiology)</term><term>Colitis, Ulcerative (genetics)</term><term>Colorectal Neoplasms (epidemiology)</term><term>Colorectal Neoplasms (etiology)</term><term>Colorectal Neoplasms (genetics)</term><term>Crohn Disease (complications)</term><term>Crohn Disease (epidemiology)</term><term>Crohn Disease (genetics)</term><term>European Continental Ancestry Group</term><term>Gene Frequency</term><term>Genetic Predisposition to Disease</term><term>Genome-Wide Association Study</term><term>Humans</term><term>Microsatellite Instability</term><term>Microsatellite Repeats (genetics)</term><term>Polymorphism, Single Nucleotide</term><term>Risk</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Fréquence d'allèle</term><term>Humains</term><term>Instabilité des microsatellites</term><term>Maladie de Crohn ()</term><term>Maladie de Crohn (génétique)</term><term>Maladie de Crohn (épidémiologie)</term><term>Polymorphisme de nucléotide simple</term><term>Population d'origine européenne</term><term>Prédisposition génétique à une maladie</term><term>Rectocolite hémorragique ()</term><term>Rectocolite hémorragique (génétique)</term><term>Rectocolite hémorragique (épidémiologie)</term><term>Risque</term><term>Répétitions microsatellites (génétique)</term><term>Tumeurs colorectales (génétique)</term><term>Tumeurs colorectales (épidémiologie)</term><term>Tumeurs colorectales (étiologie)</term><term>Étude d'association pangénomique</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Colitis, Ulcerative</term><term>Crohn Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Colitis, Ulcerative</term><term>Colorectal Neoplasms</term><term>Crohn Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Colorectal Neoplasms</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Colitis, Ulcerative</term><term>Colorectal Neoplasms</term><term>Crohn Disease</term><term>Microsatellite Repeats</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Maladie de Crohn</term><term>Rectocolite hémorragique</term><term>Répétitions microsatellites</term><term>Tumeurs colorectales</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Maladie de Crohn</term><term>Rectocolite hémorragique</term><term>Tumeurs colorectales</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Tumeurs colorectales</term></keywords><keywords scheme="MESH" xml:lang="en"><term>European Continental Ancestry Group</term><term>Gene Frequency</term><term>Genetic Predisposition to Disease</term><term>Genome-Wide Association Study</term><term>Humans</term><term>Microsatellite Instability</term><term>Polymorphism, Single Nucleotide</term><term>Risk</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Fréquence d'allèle</term><term>Humains</term><term>Instabilité des microsatellites</term><term>Maladie de Crohn</term><term>Polymorphisme de nucléotide simple</term><term>Population d'origine européenne</term><term>Prédisposition génétique à une maladie</term><term>Rectocolite hémorragique</term><term>Risque</term><term>Étude d'association pangénomique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p>We identified the minor allele (T) in SNP rs11676348 to have pleiotropic effect on risk of UC and CRC, particularly in tumors with an inflammatory component. Our findings offer the promise of risk stratification of UC patients for developing CRC.</p></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>France</li><li>Japon</li><li>Nouvelle-Zélande</li><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Khalili, Hamed" sort="Khalili, Hamed" uniqKey="Khalili H" first="Hamed" last="Khalili">Hamed Khalili</name></noRegion><name sortKey="Austin, Thomas R" sort="Austin, Thomas R" uniqKey="Austin T" first="Thomas R." last="Austin">Thomas R. Austin</name><name sortKey="Baron, John A" sort="Baron, John A" uniqKey="Baron J" first="John A." last="Baron">John A. Baron</name><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I." last="Berndt">Sonja I. Berndt</name><name sortKey="Campbell, Peter T" sort="Campbell, Peter T" uniqKey="Campbell P" first="Peter T." last="Campbell">Peter T. Campbell</name><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T." last="Chan">Andrew T. Chan</name><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T." last="Chan">Andrew T. Chan</name><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><name sortKey="Chen, Constance" sort="Chen, Constance" uniqKey="Chen C" first="Constance" last="Chen">Constance Chen</name><name sortKey="Conti, David V" sort="Conti, David V" uniqKey="Conti D" first="David V." last="Conti">David V. Conti</name><name sortKey="Duggan, David" sort="Duggan, David" uniqKey="Duggan D" first="David" last="Duggan">David Duggan</name><name sortKey="Fuchs, Charles S" sort="Fuchs, Charles S" uniqKey="Fuchs C" first="Charles S." last="Fuchs">Charles S. Fuchs</name><name sortKey="Fuchs, Charles S" sort="Fuchs, Charles S" uniqKey="Fuchs C" first="Charles S." last="Fuchs">Charles S. Fuchs</name><name sortKey="Gala, Manish" sort="Gala, Manish" uniqKey="Gala M" first="Manish" last="Gala">Manish Gala</name><name sortKey="Gong, Jian" sort="Gong, Jian" uniqKey="Gong J" first="Jian" last="Gong">Jian Gong</name><name sortKey="Haile, Robert W" sort="Haile, Robert W" uniqKey="Haile R" first="Robert W." last="Haile">Robert W. Haile</name><name sortKey="Haiman, Chris" sort="Haiman, Chris" uniqKey="Haiman C" first="Chris" last="Haiman">Chris Haiman</name><name sortKey="Harrison, Tabitha A" sort="Harrison, Tabitha A" uniqKey="Harrison T" first="Tabitha A." last="Harrison">Tabitha A. Harrison</name><name sortKey="Hayes, Richard" sort="Hayes, Richard" uniqKey="Hayes R" first="Richard" last="Hayes">Richard Hayes</name><name sortKey="Hazra, Aditi" sort="Hazra, Aditi" uniqKey="Hazra A" first="Aditi" last="Hazra">Aditi Hazra</name><name sortKey="Henderson, Brian" sort="Henderson, Brian" uniqKey="Henderson B" first="Brian" last="Henderson">Brian Henderson</name><name sortKey="Hsu, Li" sort="Hsu, Li" uniqKey="Hsu L" first="Li" last="Hsu">Li Hsu</name><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J." last="Hudson">Thomas J. Hudson</name><name sortKey="Hutter, Carolyn M" sort="Hutter, Carolyn M" uniqKey="Hutter C" first="Carolyn M." last="Hutter">Carolyn M. Hutter</name><name sortKey="Jenkins, Mark A" sort="Jenkins, Mark A" uniqKey="Jenkins M" first="Mark A." last="Jenkins">Mark A. Jenkins</name><name sortKey="Jiao, Shuo" sort="Jiao, Shuo" uniqKey="Jiao S" first="Shuo" last="Jiao">Shuo Jiao</name><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N." last="Kolonel">Laurence N. Kolonel</name><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><name sortKey="Lacroix, Andrea" sort="Lacroix, Andrea" uniqKey="Lacroix A" first="Andrea" last="Lacroix">Andrea Lacroix</name><name sortKey="Lindor, Noralane M" sort="Lindor, Noralane M" uniqKey="Lindor N" first="Noralane M." last="Lindor">Noralane M. Lindor</name><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name><name sortKey="Manson, Joann E" sort="Manson, Joann E" uniqKey="Manson J" first="Joann E." last="Manson">Joann E. Manson</name><name sortKey="Marchand, Loic Le" sort="Marchand, Loic Le" uniqKey="Marchand L" first="Loic Le" last="Marchand">Loic Le Marchand</name><name sortKey="Nan, Hongmei" sort="Nan, Hongmei" uniqKey="Nan H" first="Hongmei" last="Nan">Hongmei Nan</name><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A." last="Newcomb">Polly A. Newcomb</name><name sortKey="Ng, Kimmie" sort="Ng, Kimmie" uniqKey="Ng K" first="Kimmie" last="Ng">Kimmie Ng</name><name sortKey="Nishihara, Reiko" sort="Nishihara, Reiko" uniqKey="Nishihara R" first="Reiko" last="Nishihara">Reiko Nishihara</name><name sortKey="Nishihara, Reiko" sort="Nishihara, Reiko" uniqKey="Nishihara R" first="Reiko" last="Nishihara">Reiko Nishihara</name><name sortKey="Ogino, Shuji" sort="Ogino, Shuji" uniqKey="Ogino S" first="Shuji" last="Ogino">Shuji Ogino</name><name sortKey="Ogino, Shuji" sort="Ogino, Shuji" uniqKey="Ogino S" first="Shuji" last="Ogino">Shuji Ogino</name><name sortKey="Ogino, Shuji" sort="Ogino, Shuji" uniqKey="Ogino S" first="Shuji" last="Ogino">Shuji Ogino</name><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><name sortKey="Potter, John D" sort="Potter, John D" uniqKey="Potter J" first="John D." last="Potter">John D. Potter</name><name sortKey="Potter, John D" sort="Potter, John D" uniqKey="Potter J" first="John D." last="Potter">John D. Potter</name><name sortKey="Qu, Conghui" sort="Qu, Conghui" uniqKey="Qu C" first="Conghui" last="Qu">Conghui Qu</name><name sortKey="Schoen, Robert E" sort="Schoen, Robert E" uniqKey="Schoen R" first="Robert E." last="Schoen">Robert E. Schoen</name><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R." last="Schumacher">Fredrick R. Schumacher</name><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name><name sortKey="Slattery, Martha L" sort="Slattery, Martha L" uniqKey="Slattery M" first="Martha L." last="Slattery">Martha L. Slattery</name><name sortKey="Taverna, Darin" sort="Taverna, Darin" uniqKey="Taverna D" first="Darin" last="Taverna">Darin Taverna</name><name sortKey="Thibodeau, Stephen" sort="Thibodeau, Stephen" uniqKey="Thibodeau S" first="Stephen" last="Thibodeau">Stephen Thibodeau</name><name sortKey="Wactawski Wende, Jean" sort="Wactawski Wende, Jean" uniqKey="Wactawski Wende J" first="Jean" last="Wactawski-Wende">Jean Wactawski-Wende</name><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name><name sortKey="Wu, Kana" sort="Wu, Kana" uniqKey="Wu K" first="Kana" last="Wu">Kana Wu</name><name sortKey="Zanke, Brent W" sort="Zanke, Brent W" uniqKey="Zanke B" first="Brent W." last="Zanke">Brent W. Zanke</name></country><country name="Allemagne"><noRegion><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name></noRegion><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><name sortKey="Hoffmeister, Michael" sort="Hoffmeister, Michael" uniqKey="Hoffmeister M" first="Michael" last="Hoffmeister">Michael Hoffmeister</name></country><country name="Japon"><noRegion><name sortKey="Baba, Yoshifumi" sort="Baba, Yoshifumi" uniqKey="Baba Y" first="Yoshifumi" last="Baba">Yoshifumi Baba</name></noRegion><name sortKey="Morikawa, Teppei" sort="Morikawa, Teppei" uniqKey="Morikawa T" first="Teppei" last="Morikawa">Teppei Morikawa</name></country><country name="France"><noRegion><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stéphane" last="Bézieau">Stéphane Bézieau</name></noRegion><name sortKey="Kury, Sebastien" sort="Kury, Sebastien" uniqKey="Kury S" first="Sébastien" last="Küry">Sébastien Küry</name></country><country name="Canada"><noRegion><name sortKey="Caan, Bette" sort="Caan, Bette" uniqKey="Caan B" first="Bette" last="Caan">Bette Caan</name></noRegion><name sortKey="Gallinger, Steven" sort="Gallinger, Steven" uniqKey="Gallinger S" first="Steven" last="Gallinger">Steven Gallinger</name><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J." last="Hudson">Thomas J. Hudson</name><name sortKey="Lemire, Mathieu" sort="Lemire, Mathieu" uniqKey="Lemire M" first="Mathieu" last="Lemire">Mathieu Lemire</name></country><country name="Australie"><noRegion><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name></noRegion></country><country name="Nouvelle-Zélande"><noRegion><name sortKey="Potter, John D" sort="Potter, John D" uniqKey="Potter J" first="John D." last="Potter">John D. Potter</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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